cellular metabolism – Communicable Diseases Research

Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic control

Research article

Published on 2022-12-012022-10-05
Journal: Biochimica et biophysica acta. Molecular basis of
[Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication
[DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article

SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expression

Article

Published on 2022-11-012022-11-16
Journal: Life sciences
[Category] SARS, 유전자 메커니즘,

[키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression TMPRSS2. uninfected cell various tissue viral infection Viral load viral replication were assessed western blot
[DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

Article

Published on 2022-09-122022-11-15
Journal: PLoS Pathogens
[Category] SARS, 치료제,

Role of Cellular Metabolism in the Formation of Neutrophil Extracellular Traps in Airway Diseases

Review

Published on 2022-04-122023-07-09
Journal: Frontiers in Immunology
[Category] COVID19(2023년),

[키워드] Airway inflammation cellular metabolism Innate immunity NETs neutrophils.
[DOI] 10.3389/fimmu.2022.850416 PMC 바로가기 [Article Type] Review

Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2

SARS-CoV-2에 감염된 상피 조직 패치에 대한 항바이러스 타이밍, 효능 및 이질성 효과의 다중 스케일 모델

Article

Published on 2022-03-142022-09-11
Journal: Viruses
[Category] SARS, 치료제,

[키워드] Affect agent agent-based model Antiviral antiviral therapies antiviral therapy Cell cell-to-cell variability cellular cellular metabolism cellular uptake dosage dose Effect Efficacy epithelial Epithelial Tissue Frequency homogeneous include Infection likelihood lowest lung tissue metabolism metabolite Model mPBPK multiscale model outcome outcomes parameters patch permeability pharmacokinetic potency predict Remdesivir SARS-CoV-2 significantly Super-spreader tissue tissue model treat Treatment treatment initiation Treatment outcome Variability Variation viral infection viral infections virtual tissue simulation.
[DOI] 10.3390/v14030605 PMC 바로가기 [Article Type] Article

Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives

Review

Published on 2022-01-252022-10-31
Journal: Cellular and Molecular Life Sciences
[Category] COVID-19,

[키워드] affecting Anti-citrullinated proteins antibodies (ACPAs) arginine Autoimmune biochemical Cancer Cell cellular metabolism chromatin Citrullination citrulline clinical trial consequence conserved COVID-19 enzyme Evidence expressed function Gene Expression glycosylation human tissues immune disorders Inflammatory inflammatory disease information inhibitor less metabolism Methylation modulating multiple sclerosis neutrophil extracellular traps (NETs) Numerous pathology pathway peptidylarginine deiminases (PADs) Periodontitis Perspective Phosphorylation post-translational modification prevalent Protein Proteins rheumatoid arthritis subject systemic lupus erythematosus Therapeutic approach Thromboembolism variety
[DOI] 10.1007/s00018-022-04126-3 PMC 바로가기 [Article Type] Review

Cellular metabolic basis of altered immunity in the lungs of patients with COVID-19

Original Investigation

Published on 2022-01-132023-06-15
Journal: Medical Microbiology and Immunology
[Category] COVID19(2023년), MERS, SARS,

[키워드] cellular metabolism COVID-19 Glycolysis host immunity RNA sequencing
[DOI] 10.1007/s00430-021-00727-0 PMC 바로가기 [Article Type] Original Investigation

Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage

항체 생산으로의 이동 - 영양소, 신호 전달, 성숙한 B 계통의 세포 대사 프로그래밍 제공

Review

Published on 2021-11-152022-09-11
Journal: Cellular and Molecular Immunology
[Category] Fulltext, MERS, 유전자 메커니즘, 진단,

[키워드] antibody B lymphocyte Cell cell surface receptor cell surface receptors cell type cell types cellular cellular metabolism COVID cytokine Cytokines elicit enzyme exhibiting Fatty acid focus gene transcription Germinal centres Glucose Glutamine Glycoproteins immune defense Infection Intermediary metabolism interstitium lead Lineage Lymphocytes mechanism metabolism microbe microbes microenvironment molecular nutrient pandemic Plasma cell Plasma cells plasmablast plasmablasts programming proliferate receive Recognition regulate secrete secreted secreting secretion Signal transduction Signaling Somatic hypermutation Stage sustained the cells Transcription translation turn Vaccine
[DOI] 10.1038/s41423-021-00782-w PMC 바로가기 [Article Type] Review

The metabolic roots of senescence: mechanisms and opportunities for intervention

Reviews

Published on 2021-10-192022-10-05
Journal: Nature metabolism
[Category] 신약개발,

The roles of lipids in SARS-CoV-2 viral replication and the host immune response

Review

Published on 2021-09-292022-10-29
Journal: Journal of Lipid Research
[Category] COVID-19,

[키워드] AA, arachidonic acid ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome affecting Antiviral strategies ARDS, acute respiratory distress syndrome cell membrane cellular metabolism cholesterol coronavirus COVID-19 cysLT, cysteinyl leukotriene DC, dendritic cell eicosanoid Eicosanoids EPA, eicosapentaenoic acid Host immune response IAV, influenza A virus identify Infection IPr, IP receptor knowledge LA, linoleic acid Lipid lipid composition lipid mediator lipid metabolism Lipidomics LOX, lipoxygenase LPL, lysophospholipid mechanism membrane MERS-CoV, Middle East respiratory syndrome related coronavirus morbidity and mortality NPC1, NPC intracellular cholesterol transporter 1 offer PG, prostaglandin PGI₂, prostacyclin Phospholipids receptor regulate RO, replication organelle RSV, respiratory syncytial virus S, spike S1P, sphingosine-1-phosphate SARS-CoV-2 SARS-CoV-2 viral replication SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SK, sphingosine kinase sphingolipids SR-B1, scavenger receptor B type 1 therapeutic Tx, thromboxane viral burden viral entry viral infection viral life cycle virions virus
[DOI] 10.1016/j.jlr.2021.100129 PMC 바로가기 [Article Type] Review